intrinsic factor

intrinsic factor
   One of two proteins secreted from the lining of the stomach whose sole purpose is (it seems) to cradle B12 in a pre-fitted styrofoam mold and (A) carry it through the Seven Levels of Digestive Hell until it reaches those few absorption sites in the last foot of small intestine that understand its "Special Needs" (sounds either sexually kinky or the airplane dinner label on kosher food for flying Hassidim jewelers) and finally (B) slip it from one protein to the other, and thence into the cell membranes where its handed over to (C) the specialized blood protein that can carry it safely to the final target tissues (3 times out of 4, the bone marrow). Apparently cyanocobalamin (B12) has parts that fall off, radicals that twirl around in five directions on three charge potentials, and is as durable as a 49 cent water pistol. And, if we have an ulcer, chronic enteritis or long-standing steatorrhea, we either get B12 shots (and hope the liver still makes that blood carrier) or walk vaguely around with pernicious anemia and a hematocrit of 16.

Herbal-medical glossary. 2015.

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Look at other dictionaries:

  • intrinsic factor — n a substance produced by the normal gastrointestinal mucosa that facilitates absorption of vitamin B12 * * * a glycoprotein secreted in the stomach. The secretion of intrinsic factor is necessary for the absorption of vitamin B12; a failure of… …   Medical dictionary

  • intrinsic factor — intrinsic factor, in den Belegzellen der Magenschleimhaut gebildetes Glykoprotein, das mit ⇒ Cobalamin zu einem Komplex zusammentritt und so die Resorption dieses Vitamins im Dünndarm ermöglicht. Wird i. f. in unzureichendem Maß gebildet, kommt… …   Deutsch wörterbuch der biologie

  • intrinsic factor — n. a substance secreted by the stomach which permits the absorption of vitamin B12 in the intestines, thus preventing pernicious anemia …   English World dictionary

  • Intrinsic factor — protein Name = Gastric intrinsic factor caption = width = HGNCid = 4268 Symbol = GIF AltSymbols = EntrezGene = 2694 OMIM = 609342 RefSeq = NM 005142 UniProt = P27352 PDB = ECnumber = Chromosome = 11 Arm = q Band = 13 LocusSupplementaryData =… …   Wikipedia

  • intrinsic factor — Biochem. a glycoprotein, secreted by the gastric mucosa, that is involved in the intestinal absorption of vitamin B12. [1925 30] * * * ▪ protein       a glycoprotein (i.e., a complex compound containing both polysaccharide and protein components) …   Universalium

  • Intrinsic Factor — Der Intrinsic Faktor ist ein Glykoprotein und dient der Aufnahme von Cobalamin (Vitamin B12, Extrinsic Factor) im terminalen Ileum (Hüftdarm). Inhaltsverzeichnis 1 Physiologische Bedeutung 2 Wirkungsweise 3 Krankheiten 4 Literatur …   Deutsch Wikipedia

  • intrinsic factor — a glycoprotein secreted in the stomach. The secretion of intrinsic factor is necessary for the absorption of vitamin B 12; a failure of secretion of intrinsic factor leads to a deficiency of the vitamin and the condition of pernicious anaemia …   The new mediacal dictionary

  • Intrinsic factor — In|trinsic factor [intrịnßik fạ̈kter; aus gleichbed. engl. intrinsic factor (eigtl. = von innen wirkender Faktor)] m; [s], s: Bezeichnung für ein normalerweise in den Fundusdrüsen des Magens u. im oberen Abschnitt des Zwölffingerdarms… …   Das Wörterbuch medizinischer Fachausdrücke

  • Intrinsic Factor — In|trin|sic Fac|tor [ fæktə] der; [s], s <aus gleichbed. engl. intrinsic factor, eigtl. »von innen wirkender Faktor«> Bez. für ein in den ↑Fundusdrüsen des Magens u. im oberen Abschnitt des Zwölffingerdarms produziertes Enzym, das zusammen… …   Das große Fremdwörterbuch

  • intrinsic factor — noun a substance produced by the mucosa of the stomach and intestines that is essential for the absorption of vitamin B12 lack of intrinsic factor can result in pernicious anemia • Hypernyms: ↑factor …   Useful english dictionary

  • intrinsic factor — A mucoprotein normally secreted by the epithelium of the stomach and that binds vitamin B12; the intrinsic factor/B12 complex is selectively absorbed by the distal ileum, though only the vitamin is taken into the cell …   Dictionary of molecular biology

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